Saxagliptin Impurity 32 HCl CAS 1564266-00-7 (free base)
| CAS No. | 1564266-00-7 (free base) |
| Molecular Formula | C18H25N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Saxagliptin Impurity 32 HCl (CAS 1564266-00-7 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C18H25N3O2HCl and a molecular weight of 351.88 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Saxagliptin Impurity 32 HCl is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 351.88 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Saxagliptin Impurity 32 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H25N3O2 HCl |
| Molecular Weight | 351.88 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Saxagliptin Standards
- Saxagliptin Impurity N1 (CAS 102502-64-7)
- Saxagliptin Hydrochloride Dihydrate (CAS 1073057-20-1)
- Saxagliptin Impurity N52 (CAS 1194836-75-3)
- Saxagliptin Cyclic Imidine Impurity (CAS 1194836-77-5)
- (±)-Saxagliptin-13C3 (acetyl-13C2,cyclopropyl-3-13C) (CAS 1246812-44-1)
- Saxagliptin-15N,D2 Hydrochloride (CAS 1309934-06-2)
- Saxagliptin Impurity 60 Mesylate (CAS 1312338-82-1)
- Saxagliptin Impurity 6 (CAS 1334321-39-9)
Recommended Standards
- Nebivolol Impurity 56 (CAS CATO-C4X-196856)
- Piperidine Impurity 23 (CAS CATO-C4X-239923)
- Regadenoson Impurity 11 (CAS 24723-77-1)
- 2-Bromo-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (CAS 1339344-06-7)
- 1-(2-Methylbutyl)-1h-1,2,4-triazol-3-amine (CAS 1250156-76-3)
- 3,3'-Methylenebis(1-tert-butyl-3-imidazolium Bromide) (CAS 247902-48-3)
- (1R,4S,5R,6R)-spiro[bicyclo[2.2.1]Heptane-7,1'-cyclopropan]-2-ene-5,6-dicarboxylic acid (CAS 1256276-79-5)
- 5-Amino-4-(4-(4-chlorophenyl)thiazol-2-yl)-1-phenyl-1,2-dihydro-3H-pyrrol-3-one (CAS 380386-92-5)
- 5-Isobutyl-2,3-dimethylpyrazine (CAS 54410-83-2)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
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